KIF5B

Across TCGA pan-cancer cohorts, KIF5B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KIF5B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where KIF5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIF5B is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LIHC, HNSC, and KIRC are the cancer types where KIF5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.064	<.001	8	view →
HNSC	All	II,III,IV	+0.402	.002	6	view →
KIRC	Male	II,III,IV	−0.373	.006	6	view →
STAD	All	II,III,IV	+0.877	<.001	5	view →
KICH	Female	All	−0.876	<.001	5	view →
COAD	Male	All	+0.655	<.001	4	view →
CHOL	Male	All	+2.531	<.001	3	view →
READ	All	III,IV	+0.974	.041	2	view →
ESCA	All	All	+0.773	.006	2	view →
THCA	All	All	−0.193	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KIF5B–LIHC

Open the LIHC breakdown →