KIF5B

Across TCGA patient cohorts, KIF5B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF5B-associated genes across cancer lineages are ATM, mTOR_pS2448, and PCNA. Each is linked with KIF5B in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF5B-to-partner and partner-to-KIF5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KIF5B-low versus KIF5B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5B→partner) and Y-score (partner→KIF5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.817	-3.161	<.001	.019	3	4
UCEC	mTOR_pS2448 →	-0.128	-1.459	.008	.012	3	3
UCEC	PCNA →	+0.240	+1.716	<.001	.003	3	3
UCEC	Shc_pY317 →	-0.133	-2.000	.006	<.001	3	3
UCEC	c-Met_pY1235 →	+0.069	+1.290	.004	.034	3	3
COAD	Rad50 →	-0.418	-3.161	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by KIF5B expression — COAD

Explore this box plot interactively →