KIF4A

Across TCGA pan-cancer cohorts, KIF4A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIF4A data layer compared with 29 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KIF4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KIF4A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, OV, and LUAD are the cancer types where KIF4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.747	1.000	.002	30	view →
OV	DFS	Median	All	0.676	0.923	.039	16	view →
LUAD	DFS	Tertile	All	0.459	0.915	.020	9	view →
LSCC	OS	Tertile	All	0.915	0.707	.045	2	view →
HNSC	DFS	Quartile	III,IV	0.500	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIF4A–PDAC (OS)

Open the PDAC breakdown →