KIF3C

Across TCGA pan-cancer cohorts, KIF3C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KIF3C data layer compared with 27 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KIF3C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIF3C expression acts as an unfavorable survival marker.

COAD, LIHC, and UCEC are the cancer types where KIF3C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.152	0.679	<.001	22	view →
LIHC	OS	Median	All	0.198	0.777	.006	18	view →
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
LUAD	DFS	Median	II,III,IV	0.036	0.682	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KIF3C–COAD (OS)

Open the COAD breakdown →