KIF3A

Across TCGA cell cohorts, KIF3A mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF3A-associated genes across cancer lineages are TXNDC8, TPRX1, and BEND2. Each is linked with KIF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF3A-to-partner and partner-to-KIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNDC8 grouped by KIF3A-low versus KIF3A-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF3A→partner) and Y-score (partner→KIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TXNDC8 →	+0.013	+5.000	<.001	.005	3	2
LUNG_NSCLC_LUAD	TPRX1 →	+0.012	+3.215	<.001	.007	3	2
LARGE_INTESTINE	BEND2 →	+0.013	+3.240	<.001	.004	3	2
KIDNEY	NKX2-6 →	+0.053	+5.000	<.001	.005	3	1
KIDNEY	OR2AK2 →	+0.020	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	OTOP1 →	+0.011	+3.215	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TXNDC8 by KIF3A expression — KIDNEY

Explore this box plot interactively →