KIF2C

Across TCGA patient cohorts, KIF2C mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF2C-associated genes across cancer lineages are 14-3-3_beta, p62 Lck ligand, and P-Cadherin. Each is linked with KIF2C in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF2C-to-partner and partner-to-KIF2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by KIF2C-low versus KIF2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF2C→partner) and Y-score (partner→KIF2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.101	-2.195	.004	.009	3	2
UCEC	p62 Lck ligand →	+0.381	+2.874	<.001	<.001	3	2
UCEC	P-Cadherin →	-0.115	-2.000	.023	.029	3	2
UCEC	Rad50 →	-0.172	-2.000	.045	.003	3	2
UCEC	STAT3_pY705 →	-0.333	-1.662	<.001	.011	3	2
UCEC	ASNS →	+0.484	+1.678	<.001	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by KIF2C expression — UCEC

Explore this box plot interactively →