KIF2C

Across TCGA pan-cancer cohorts, KIF2C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated KIF2C data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KIF2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF2C expression acts as an unfavorable survival marker, although some lineages such as SCLC and GBM show a favorable association.

ACC, KIRP, and MESO are the cancer types where KIF2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.192	0.700	<.001	167	view →
KIRP	OS	Median	All	0.552	0.793	<.001	155	view →
MESO	OS	Median	All	0.363	0.715	<.001	120	view →
KIRC	DFS	Median	All	0.548	0.699	<.001	120	view →
KICH	OS	Median	III,IV	0.363	0.957	<.001	107	view →
LIHC	DFS	Median	All	0.420	0.662	<.001	100	view →
SCLC	OS	Tertile	II,III,IV	0.682	0.256	.001	71	view →
LGG	DFS	Median	All	0.639	0.842	<.001	54	view →
LUAD	OS	Tertile	All	0.614	0.774	<.001	49	view →
THCA	DFS	Quartile	II,III,IV	0.562	0.963	.001	47	view →
PAAD	DFS	Quartile	All	0.167	0.498	<.001	40	view →
SKCM	DFS	Tertile	II,III,IV	0.142	0.426	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

KIF2C–ACC (DFS)

Open the ACC breakdown →