KIF2A

Across TCGA pan-cancer cohorts, KIF2A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KIF2A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where KIF2A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KIF2A is over-expressed in tumor.

CCRCC, LUAD, and COAD are the cancer types where KIF2A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF2A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	III,IV	+0.736	<.001	11	view →
LUAD	Male	III,IV	+0.349	<.001	9	view →
COAD	Male	All	+0.281	<.001	9	view →
HNSC	Male	IV	+0.317	<.001	8	view →
PDAC	Male	All	+0.380	<.001	7	view →
LSCC	Male	All	+0.244	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KIF2A–CCRCC

Open the CCRCC breakdown →