KIF2A

Across TCGA patient cohorts, KIF2A mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF2A-associated genes across cancer lineages are eEF2, NF-kB-p65_pS536, and PKC-b-II_pS660. Each is linked with KIF2A in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF2A-to-partner and partner-to-KIF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KIF2A-low versus KIF2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF2A→partner) and Y-score (partner→KIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.287	+2.321	.026	.033	3	2
UCEC	NF-kB-p65_pS536 →	-0.386	-3.459	.018	.005	3	2
UCEC	PKC-b-II_pS660 →	-0.206	-1.584	.038	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.488	+1.720	.022	.025	3	2
UCEC	4E-BP1 →	+0.287	+2.145	.003	.009	3	2
UCEC	A-Raf_pS299 →	-0.110	-2.000	.010	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by KIF2A expression — UCEC

Explore this box plot interactively →