KIF26B

Across TCGA pan-cancer cohorts, KIF26B Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated KIF26B data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIF26B Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF26B expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

UCEC, READ, and SCLC are the cancer types where KIF26B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.912	0.297	.002	34	view →
READ	OS	Median	All	0.198	0.829	.001	18	view →
SCLC	OS	Median	II,III,IV	1.000	0.260	.009	12	view →
STAD	DFS	Median	All	0.774	0.373	.010	12	view →
ACC	DFS	Median	All	0.057	0.623	.001	9	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	8	view →
BLCA	DFS	Median	IV	0.094	0.480	.001	6	view →
ESCA	DFS	Median	III,IV	0.080	0.442	.007	6	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	6	view →
KIRP	DFS	Median	All	0.133	0.605	.014	3	view →
GBM	DFS	Median	All	0.031	0.243	<.001	3	view →
LIHC	OS	Median	III,IV	0.408	0.657	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

KIF26B–UCEC (DFS)

Open the UCEC breakdown →