KIF26B

Across TCGA pan-cancer cohorts, KIF26B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KIF26B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIF26B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIF26B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where KIF26B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF26B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.661	<.001	12	view →
BLCA	Female	III,IV	+2.591	<.001	12	view →
COAD	Male	IV	+1.528	<.001	11	view →
LUAD	Male	III,IV	+2.854	<.001	9	view →
LUSC	Female	II,III,IV	+2.614	<.001	9	view →
KIRC	Male	II,III,IV	−1.020	<.001	9	view →
LIHC	All	All	+0.457	<.001	7	view →
BRCA	All	III,IV	+2.210	<.001	6	view →
UCEC	All	All	+1.907	<.001	6	view →
STAD	Male	II,III,IV	+1.871	<.001	6	view →
CHOL	All	II,III,IV	+4.930	<.001	5	view →
READ	All	All	+1.568	.006	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KIF26B–HNSC

Open the HNSC breakdown →