KIF25-AS1

Across TCGA pan-cancer cohorts, KIF25-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KIF25-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KIF25-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF25-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UCEC, and DLBC are the cancer types where KIF25-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.398	0.276	.002	79	view →
UCEC	DFS	Median	All	0.791	0.881	.001	36	view →
DLBC	DFS	Tertile	All	0.406	1.000	.014	30	view →
LIHC	OS	Quartile	All	0.673	0.819	.001	29	view →
STAD	DFS	Quartile	All	0.241	0.468	.005	27	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
BLCA	DFS	Median	IV	0.307	0.558	.027	17	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	15	view →
UCS	DFS	Tertile	IV	0.996	0.812	.049	12	view →
COAD	OS	Quartile	III,IV	0.459	0.743	.010	11	view →
GBM	OS	Tertile	All	0.215	0.337	.036	10	view →
MESO	OS	Quartile	All	0.306	0.498	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KIF25-AS1–HNSC (DFS)

Open the HNSC breakdown →