KIF23

Across TCGA patient cohorts, KIF23 mutation is significantly associated with the RNA expression of many other genes, with 2,805 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF23-associated genes across cancer lineages are RNU4-79P, DDX41, and MIR3661. Each is linked with KIF23 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF23-to-partner and partner-to-KIF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-79P grouped by KIF23-low versus KIF23-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF23→partner) and Y-score (partner→KIF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU4-79P →	+0.298	+7.977	<.001	.007	3	3
UCEC	DDX41 →	+0.319	+1.935	<.001	<.001	3	3
UCEC	MIR3661 →	+0.606	+1.659	<.001	.001	3	3
UCEC	MPI →	+0.332	+1.457	.003	.006	3	2
UCEC	RCC1 →	+0.376	+2.818	.005	.001	3	2
UCEC	FDX1P1 →	+0.223	+1.641	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,805 associations by consensus.

RNU4-79P by KIF23 expression — LGG

Explore this box plot interactively →