KIF21B

Across TCGA pan-cancer cohorts, KIF21B mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KIF21B’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where KIF21B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KIF21B is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where KIF21B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF21B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+1.729	.001	4	view →
LSCC	Male	All	−0.458	<.001	4	view →
LUAD	All	All	−0.237	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

KIF21B–PDAC

Open the PDAC breakdown →