KIF21B

Across TCGA pan-cancer cohorts, KIF21B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KIF21B data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher KIF21B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF21B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

UVM, LUSC, and HNSC are the cancer types where KIF21B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.421	0.729	<.001	92	view →
LUSC	OS	Quartile	All	0.281	0.471	.001	69	view →
HNSC	DFS	Quartile	III,IV	0.486	0.215	.001	63	view →
UCS	OS	Tertile	II,III,IV	0.608	0.217	.003	54	view →
LGG	DFS	Median	All	0.509	0.305	<.001	47	view →
BLCA	OS	Median	III,IV	0.761	0.604	.003	37	view →
SKCM	OS	Tertile	II,III,IV	0.463	0.270	.003	28	view →
PAAD	DFS	Tertile	II,III,IV	0.544	0.345	.002	28	view →
CESC	DFS	Quartile	All	0.739	0.912	.001	28	view →
STAD	DFS	Median	All	0.718	0.536	<.001	24	view →
SCLC	OS	Median	All	0.754	0.528	.005	20	view →
LAML	DFS	Tertile	All	0.280	0.525	.006	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KIF21B–UVM (DFS)

Open the UVM breakdown →