KIF21B

Across TCGA patient cohorts, KIF21B mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF21B-associated genes across cancer lineages are ATM, ASNS, and Cyclin-B1. Each is linked with KIF21B in more than 4 cancer types. Because this analysis shows association rather than direction, both KIF21B-to-partner and partner-to-KIF21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KIF21B-low versus KIF21B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF21B→partner) and Y-score (partner→KIF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.394	-2.188	<.001	<.001	3	5
LUSC	ASNS →	+0.500	+2.124	.004	.010	3	4
LUSC	Cyclin-B1 →	+0.413	+1.594	.019	.043	3	4
STAD	eEF2 →	+0.425	+3.321	.002	.010	3	3
LUSC	GAPDH →	+0.717	+2.124	.006	.010	1	5
UCEC	14-3-3_beta →	-0.086	-1.809	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

ATM by KIF21B expression — UCEC

Explore this box plot interactively →