KIF21B

Across TCGA cell cohorts, KIF21B mutation is significantly associated with the RNA expression of many other genes, with 1,283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF21B-associated genes across cancer lineages are PRAMEF14, PPIAL4A, and USP29. Each is linked with KIF21B in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF21B-to-partner and partner-to-KIF21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF14 grouped by KIF21B-low versus KIF21B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF21B→partner) and Y-score (partner→KIF21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRAMEF14 →	+0.169	+3.736	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	PPIAL4A →	+0.212	+3.528	.002	.006	3	2
STOMACH	USP29 →	+0.029	+4.044	<.001	.003	3	2
LUNG_NSCLC_LUAD	IFNG →	+0.016	+2.777	<.001	.004	3	2
LUNG_NSCLC_LUAD	ITGAD →	+0.079	+2.435	<.001	.006	3	2
LUNG_NSCLC_LUAD	PRAMEF4 →	+0.007	+2.564	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,283 associations by consensus.

PRAMEF14 by KIF21B expression — SOFT_TISSUE

Explore this box plot interactively →