KIF20A

Across TCGA patient cohorts, KIF20A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF20A-associated genes across cancer lineages are PDCD4, AMPK_alpha, and PKC-b-II_pS660. Each is linked with KIF20A in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF20A-to-partner and partner-to-KIF20A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by KIF20A-low versus KIF20A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF20A→partner) and Y-score (partner→KIF20A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.531	-3.160	.009	.019	3	2
UCEC	AMPK_alpha →	-0.164	-2.321	.048	.034	3	2
UCEC	PKC-b-II_pS660 →	-0.296	-3.169	.014	.019	3	2
UCEC	ATM →	-0.877	-3.906	<.001	<.001	3	2
UCEC	eIF4E →	+0.187	+2.115	.042	.019	3	1
UCEC	eIF4G →	+0.305	+2.115	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PDCD4 by KIF20A expression — UCEC

Explore this box plot interactively →