KIF20A

Across TCGA pan-cancer cohorts, KIF20A RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated KIF20A data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KIF20A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF20A expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

KIRP, ACC, and MESO are the cancer types where KIF20A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.747	0.954	<.001	156	view →
ACC	OS	Median	All	0.344	0.830	<.001	142	view →
MESO	OS	Median	All	0.374	0.696	<.001	126	view →
LIHC	DFS	Median	All	0.450	0.633	<.001	113	view →
UVM	DFS	Quartile	All	0.269	0.797	<.001	111	view →
KIRC	OS	Median	All	0.545	0.720	<.001	98	view →
KICH	DFS	Tertile	III,IV	0.113	1.000	<.001	94	view →
LUAD	OS	Median	All	0.608	0.759	<.001	79	view →
PAAD	OS	Median	All	0.274	0.501	<.001	71	view →
LGG	OS	Median	All	0.709	0.922	<.001	54	view →
STAD	DFS	Median	II,III,IV	0.364	0.680	.004	36	view →
SARC	DFS	Tertile	All	0.418	0.663	<.001	31	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

KIF20A–KIRP (DFS)

Open the KIRP breakdown →