KIF1C

Across TCGA pan-cancer cohorts, KIF1C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF1C data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIF1C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF1C expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where KIF1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.990	0.824	<.001	16	view →
HNSC	OS	Median	III,IV	1.000	0.449	.023	11	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	DFS	Median	All	0.631	0.791	.013	8	view →
CCRCC	OS	Tertile	All	1.000	0.607	.019	3	view →
LSCC	DFS	Median	All	0.505	0.822	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF1C–UCEC (DFS)

Open the UCEC breakdown →