KIF17

Across TCGA pan-cancer cohorts, KIF17 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KIF17 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher KIF17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF17 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

UVM, BRCA, and SCLC are the cancer types where KIF17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.419	0.755	<.001	135	view →
BRCA	OS	Tertile	All	0.672	0.545	.014	14	view →
SCLC	DFS	Median	All	0.378	0.781	.020	14	view →
ESCA	OS	Tertile	II,III,IV	0.634	0.391	.025	13	view →
LAML	DFS	Quartile	All	0.525	0.830	.016	12	view →
ACC	DFS	Median	All	0.266	0.720	.006	11	view →
THCA	DFS	Median	III,IV	0.906	0.588	.010	9	view →
UCS	OS	Median	II,III,IV	0.564	0.288	.034	8	view →
CESC	OS	Median	II,III,IV	0.633	0.301	.025	8	view →
LUAD	DFS	Tertile	II,III,IV	0.691	0.460	.019	8	view →
COAD	DFS	Median	IV	0.341	0.602	.013	7	view →
PAAD	DFS	Median	All	0.378	0.195	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KIF17–UVM (DFS)

Open the UVM breakdown →