KIF17

Across TCGA pan-cancer cohorts, KIF17 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KIF17’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KIF17 RNA is repressed in tumor relative to normal tissue. In most cancer types KIF17 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and KICH are the cancer types where KIF17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.168	<.001	11	view →
HNSC	All	III,IV	+0.805	<.001	11	view →
KICH	Female	All	−1.618	<.001	10	view →
LUSC	Female	All	−1.821	<.001	9	view →
LUAD	Female	III,IV	−1.767	<.001	9	view →
UCEC	All	All	−1.450	<.001	8	view →
BRCA	All	II,III,IV	−0.620	<.001	6	view →
COAD	Female	III,IV	−0.397	.003	3	view →
STAD	Male	IV	+1.345	.016	2	view →
BLCA	Male	IV	−1.290	.004	2	view →
PRAD	All	All	−0.460	<.001	2	view →
LIHC	All	All	+0.282	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KIF17–THCA

Open the THCA breakdown →