KIF15

Across TCGA pan-cancer cohorts, KIF15 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KIF15 data layer compared with 30 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KIF15 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF15 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, HNSC, and COAD are the cancer types where KIF15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.088	0.920	<.001	48	view →
HNSC	OS	Median	II,III,IV	0.029	0.712	<.001	30	view →
COAD	OS	Median	II,III,IV	0.467	0.856	<.001	27	view →
SARC	OS	Median	All	0.126	0.860	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	All	0.322	0.557	.040	6	view →
UCEC	DFS	Median	II,III,IV	0.852	0.301	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KIF15–KIRP (DFS)

Open the KIRP breakdown →