KIF15

Across TCGA pan-cancer cohorts, KIF15 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KIF15 data layer compared with 30 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KIF15 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where KIF15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	1.000	0.896	.021	9	view →
LSCC	OS	Tertile	All	0.899	0.717	.026	8	view →
CCRCC	DFS	Tertile	III,IV	0.193	0.819	.024	6	view →
LUAD	OS	Quartile	II,III,IV	0.243	0.871	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KIF15–HNSC (DFS)

Open the HNSC breakdown →