KIF15

Across TCGA pan-cancer cohorts, KIF15 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KIF15’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KIF15 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types KIF15 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where KIF15 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF15 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.481	<.001	10	view →
LSCC	Male	II,III,IV	+1.042	<.001	9	view →
LUAD	Male	III,IV	+0.900	<.001	8	view →
HNSC	Male	III,IV	+0.292	<.001	8	view →
CCRCC	Female	All	+0.732	.021	1	view →
PDAC	Male	II,III,IV	−0.460	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KIF15–COAD

Open the COAD breakdown →