KIF14

Across TCGA pan-cancer cohorts, KIF14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF14 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KIF14 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KIF14 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where KIF14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.693	0.324	.002	16	view →
LUAD	DFS	Median	All	0.665	1.000	.020	5	view →
HNSC	OS	Quartile	IV	0.852	0.573	.016	4	view →
LSCC	DFS	Quartile	All	0.821	0.207	.048	2	view →
GBM	DFS	Quartile	All	0.613	0.877	.021	1	view →
CCRCC	DFS	Tertile	All	1.000	0.766	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF14–PDAC (OS)

Open the PDAC breakdown →