KIF14

Across TCGA pan-cancer cohorts, KIF14 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KIF14’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where KIF14 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KIF14 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, HNSC, and CCRCC are the cancer types where KIF14 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF14 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	II,III,IV	+0.891	<.001	8	view →
HNSC	Male	III,IV	+0.595	<.001	8	view →
CCRCC	All	III,IV	−0.572	.001	8	view →
LUAD	All	II,III,IV	+0.230	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

KIF14–LSCC

Open the LSCC breakdown →