KIF12

Across TCGA patient cohorts, KIF12 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF12-associated genes across cancer lineages are Ku80, c-Met_pY1235, and MEK1. Each is linked with KIF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF12-to-partner and partner-to-KIF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by KIF12-low versus KIF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF12→partner) and Y-score (partner→KIF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.245	+2.820	.017	.035	3	2
UCEC	c-Met_pY1235 →	+0.092	+2.469	.004	.010	3	2
UCEC	MEK1 →	+0.410	+2.115	.010	.019	3	1
UCEC	Rad50 →	-0.240	-2.807	.023	.003	3	1
UCEC	Annexin_VII →	-0.122	-2.115	.045	.019	3	1
UCEC	Di-Ras3 →	-0.161	-2.115	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by KIF12 expression — UCEC

Explore this box plot interactively →