KIF12

Across TCGA pan-cancer cohorts, KIF12 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KIF12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where KIF12 RNA is repressed in tumor relative to normal tissue. In most cancer types KIF12 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where KIF12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−4.645	<.001	11	view →
THCA	Male	III,IV	−1.825	<.001	11	view →
COAD	Female	All	+1.880	<.001	10	view →
KIRC	Male	II,III,IV	−1.028	<.001	9	view →
STAD	All	All	+2.066	<.001	6	view →
LUSC	Male	All	−0.960	<.001	6	view →
KIRP	All	All	−0.893	<.001	6	view →
BLCA	All	All	+0.846	.007	5	view →
HNSC	All	All	+0.387	.021	4	view →
CHOL	All	All	+3.576	<.001	3	view →
ESCA	All	II,III,IV	+4.455	.027	2	view →
READ	Female	All	+2.130	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KIF12–KICH

Open the KICH breakdown →