KIF12

Across TCGA cell cohorts, KIF12 mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF12-associated genes across cancer lineages are SEL1L2, KLHL40, and S100G. Each is linked with KIF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF12-to-partner and partner-to-KIF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by KIF12-low versus KIF12-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF12→partner) and Y-score (partner→KIF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SEL1L2 →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	S100G →	+0.072	+4.867	<.001	.009	3	1
LARGE_INTESTINE	SLC25A11 →	+0.700	+3.364	<.001	.002	3	1
LARGE_INTESTINE	GPN3 →	+0.581	+3.064	<.001	.009	3	1
LARGE_INTESTINE	MIF4GD →	+0.549	+3.169	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

SEL1L2 by KIF12 expression — OESOPHAGUS

Explore this box plot interactively →