KIF12

Across TCGA cell cohorts, KIF12 mutation is significantly associated with the mutation status of many other genes, with 4,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF12-associated genes across cancer lineages are TBC1D1, CPSF7, and ITPR1. Each is linked with KIF12 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF12-to-partner and partner-to-KIF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D1 grouped by KIF12-low versus KIF12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF12→partner) and Y-score (partner→KIF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBC1D1 →	+4.187	+5.000	.008	.008	1	3
BLOOD_Lymphoma	CPSF7 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	ITPR1 →	+3.362	+4.754	.002	.002	1	3
BLOOD_Lymphoma	CACNB2 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	ACTBL2 →	+5.584	+5.014	.003	.003	1	3
LUNG_NSCLC_LUAD	TMCC1 →	+4.772	+5.339	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,590 associations by consensus.

TBC1D1 by KIF12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →