KIDINS220

Across TCGA patient cohorts, KIDINS220 mutation is significantly associated with the RNA expression of many other genes, with 6,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIDINS220-associated genes across cancer lineages are PKN3, PTH1R, and GNL3. Each is linked with KIDINS220 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIDINS220-to-partner and partner-to-KIDINS220 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by KIDINS220-low versus KIDINS220-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIDINS220→partner) and Y-score (partner→KIDINS220) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+0.815	+1.799	<.001	<.001	3	4
UCEC	PTH1R →	-0.611	-2.786	<.001	<.001	3	4
SKCM	GNL3 →	+0.635	+3.398	.001	<.001	3	4
UCEC	SFXN1 →	+0.519	+2.152	<.001	<.001	3	4
UCEC	PBK →	+0.884	+2.368	<.001	<.001	3	4
UCEC	NIPA1 →	+0.706	+1.809	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,328 associations by consensus.

PKN3 by KIDINS220 expression — UCEC

Explore this box plot interactively →