KIDINS220

Across TCGA patient cohorts, KIDINS220 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIDINS220-associated genes across cancer lineages are ATM, mTOR_pS2448, and Annexin-1. Each is linked with KIDINS220 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIDINS220-to-partner and partner-to-KIDINS220 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KIDINS220-low versus KIDINS220-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIDINS220→partner) and Y-score (partner→KIDINS220) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.586	-2.192	<.001	<.001	3	4
UCEC	mTOR_pS2448 →	-0.132	-2.117	.002	<.001	3	3
UCEC	Annexin-1 →	+0.511	+1.682	<.001	.006	3	3
UCEC	c-Kit →	-0.203	-1.954	.002	<.001	3	3
LUAD	P-Cadherin →	+0.270	+2.824	.026	.036	3	2
UCEC	eEF2 →	+0.342	+2.415	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

ATM by KIDINS220 expression — UCEC

Explore this box plot interactively →