KIAA2013

Across TCGA patient cohorts, KIAA2013 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA2013-associated genes across cancer lineages are Notch1, FOXO3a, and MEK1. Each is linked with KIAA2013 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA2013-to-partner and partner-to-KIAA2013 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KIAA2013-low versus KIAA2013-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA2013→partner) and Y-score (partner→KIAA2013) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.232	+3.183	.001	.009	3	2
UCEC	FOXO3a →	-0.115	-2.308	.024	.036	3	1
UCEC	MEK1 →	+0.473	+3.459	.009	.005	3	1
UCEC	PDCD4 →	-0.685	-2.999	.003	.035	3	1
UCEC	Shc_pY317 →	-0.185	-2.321	.015	.035	3	1
UCEC	Chk2_pT68 →	-0.225	-3.459	.016	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by KIAA2013 expression — UCEC

Explore this box plot interactively →