KIAA1549

Across TCGA pan-cancer cohorts, KIAA1549 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIAA1549 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KIAA1549 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIAA1549 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where KIAA1549 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.181	0.666	<.001	24	view →
LUAD	OS	Median	All	0.606	0.816	.002	17	view →
UCEC	DFS	Median	All	0.962	0.824	.007	14	view →
BRCA	OS	Median	All	0.206	0.582	.001	8	view →
KIRC	OS	Median	All	0.181	0.655	.046	6	view →
SCLC	DFS	Median	All	1.000	0.273	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIAA1549–HNSC (DFS)

Open the HNSC breakdown →