KIAA1109

Across TCGA pan-cancer cohorts, KIAA1109 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated KIAA1109 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher KIAA1109 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIAA1109 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THCA, LIHC, and UCEC are the cancer types where KIAA1109 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.698	0.983	<.001	42	view →
LIHC	OS	Median	III,IV	0.150	0.633	<.001	21	view →
UCEC	DFS	Median	All	0.783	0.620	.005	18	view →
ESCA	OS	Median	III,IV	0.108	0.574	<.001	12	view →
COAD	OS	Median	IV	0.045	0.659	<.001	10	view →
LAML	DFS	Median	All	0.056	0.572	.001	6	view →
LUAD	OS	Median	II,III,IV	0.240	0.547	.016	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BRCA	DFS	Median	All	0.758	0.904	.013	4	view →
SCLC	OS	Median	All	0.426	0.844	.042	3	view →
SKCM	OS	Median	All	0.897	0.759	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

KIAA1109–THCA (OS)

Open the THCA breakdown →