Across TCGA pan-cancer cohorts, KIAA0753 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIAA0753 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KIAA0753 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIAA0753 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where KIAA0753 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.564	0.924	.002	42	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	25	view →
LSCC	DFS	Quartile	II,III,IV	0.813	1.000	.030	3	view →
GBM	DFS	Median	All	0.439	0.237	.033	2	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.655	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: KIAA0753 tumor-vs-normal RNA expression · all KIAA0753 data types