Across TCGA pan-cancer cohorts, KIAA0753 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KIAA0753’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIAA0753 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIAA0753 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
HNSC, KICH, and LIHC are the cancer types where KIAA0753 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIAA0753 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.