KIAA0586

Across TCGA cell cohorts, KIAA0586 mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIAA0586-associated genes across cancer lineages are ZIC3, CCR8, and USP26. Each is linked with KIAA0586 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA0586-to-partner and partner-to-KIAA0586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC3 grouped by KIAA0586-low versus KIAA0586-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0586→partner) and Y-score (partner→KIAA0586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZIC3 →	+0.019	+5.060	<.001	.001	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
URINARY_TRACT	USP26 →	+0.294	+3.584	.007	.009	3	1
URINARY_TRACT	LCE3D →	+0.585	+3.584	<.001	.005	3	1
URINARY_TRACT	OR1Q1 →	+0.090	+3.643	.001	.007	3	1
URINARY_TRACT	AQP12B →	+0.140	+4.321	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

ZIC3 by KIAA0586 expression — BLOOD_Leukemia

Explore this box plot interactively →