KHSRP

Across TCGA pan-cancer cohorts, KHSRP mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KHSRP data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KHSRP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KHSRP expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where KHSRP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.750	0.948	<.001	89	view →
LSCC	OS	Median	All	0.890	0.732	.010	31	view →
PDAC	DFS	Quartile	All	0.875	0.598	.001	29	view →
COAD	DFS	Median	All	1.000	0.887	.020	12	view →
UCEC	OS	Tertile	III,IV	0.291	1.000	.021	12	view →
LUAD	OS	Tertile	III,IV	0.795	0.355	.010	11	view →
GBM	OS	Quartile	All	0.679	0.300	.024	3	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KHSRP–HNSC (OS)

Open the HNSC breakdown →