KHSRP

Across TCGA patient cohorts, KHSRP mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHSRP-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and EGFR_pY1068. Each is linked with KHSRP in more than 1 cancer types. Because this analysis shows association rather than direction, both KHSRP-to-partner and partner-to-KHSRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KHSRP-low versus KHSRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHSRP→partner) and Y-score (partner→KHSRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.224	+1.247	.015	.045	3	2
UCEC	14-3-3_beta →	-0.080	-2.558	.019	.010	3	1
UCEC	EGFR_pY1068 →	-0.286	-2.137	<.001	.001	3	1
UCEC	eIF4E →	+0.145	+2.335	.044	.018	3	1
UCEC	ERK2 →	+0.153	+2.000	.019	.029	3	1
UCEC	FoxM1 →	+0.181	+1.594	.040	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

4E-BP1 by KHSRP expression — UCEC

Explore this box plot interactively →