KHK

Across TCGA pan-cancer cohorts, KHK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KHK data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KHK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KHK expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where KHK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.603	0.351	.001	53	view →
CCRCC	OS	Tertile	All	1.000	0.881	.011	37	view →
UCEC	OS	Tertile	III,IV	0.539	0.802	.049	4	view →
HNSC	DFS	Median	All	0.673	0.455	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KHK–PDAC (OS)

Open the PDAC breakdown →