KHK

Across TCGA pan-cancer cohorts, KHK RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KHK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KHK RNA is repressed in tumor relative to normal tissue. In most cancer types KHK is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and COAD are the cancer types where KHK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KHK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−3.002	<.001	11	view →
KICH	Male	II,III,IV	−4.400	<.001	9	view →
COAD	All	All	+0.746	<.001	9	view →
UCEC	All	All	−1.174	<.001	6	view →
CHOL	Female	All	−4.210	<.001	5	view →
KIRC	All	II,III,IV	+0.916	.003	5	view →
LUSC	All	All	+0.505	.001	4	view →
THCA	All	All	−0.300	.002	4	view →
READ	All	III,IV	+1.684	.010	3	view →
BLCA	Female	All	+1.016	.014	3	view →
LIHC	All	All	−0.807	<.001	3	view →
ESCA	Female	All	+1.490	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KHK–KIRP

Open the KIRP breakdown →