KHK

Across TCGA patient cohorts, KHK mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHK-associated genes across cancer lineages are Tuberin_pT1462, Tuberin, and ASNS. Each is linked with KHK in more than 1 cancer types. Because this analysis shows association rather than direction, both KHK-to-partner and partner-to-KHK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by KHK-low versus KHK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHK→partner) and Y-score (partner→KHK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.289	+2.179	.009	.034	3	1
UCEC	Tuberin →	+0.268	+2.179	.039	.034	3	1
UCEC	ASNS →	+0.344	+3.000	.049	.036	3	1
UCEC	JNK2 →	+0.264	+3.009	.005	.019	2	1
UCEC	4E-BP1 →	+0.400	+3.199	.002	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Tuberin_pT1462 by KHK expression — UCEC

Explore this box plot interactively →