KHDC1L

Across TCGA patient cohorts, KHDC1L mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDC1L-associated genes across cancer lineages are TRDJ4, ZNF84-DT, and RNU4-58P. Each is linked with KHDC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDC1L-to-partner and partner-to-KHDC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDJ4 grouped by KHDC1L-low versus KHDC1L-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC1L→partner) and Y-score (partner→KHDC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TRDJ4 →	+0.919	+5.653	<.001	.003	3	2
COAD	ZNF84-DT →	+0.078	+3.915	.001	.004	3	2
UCEC	RNU4-58P →	+0.307	+3.133	<.001	.009	3	1
UCEC	RNU6-200P →	+0.149	+4.437	.003	.005	3	1
UCEC	SNORD116-3 →	+0.405	+3.977	<.001	<.001	3	1
UCEC	MIR23A →	+1.154	+3.637	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

TRDJ4 by KHDC1L expression — READ

Explore this box plot interactively →