KERA

Across TCGA patient cohorts, KERA mutation is significantly associated with the RNA expression of many other genes, with 1,981 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KERA-associated genes across cancer lineages are RNA5SP413, BPY2DP, and TUBGCP5. Each is linked with KERA in more than 2 cancer types. Because this analysis shows association rather than direction, both KERA-to-partner and partner-to-KERA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by KERA-low versus KERA-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KERA→partner) and Y-score (partner→KERA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP413 →	+0.906	+5.578	<.001	.004	3	3
STAD	BPY2DP →	+0.331	+5.105	<.001	.008	3	3
SKCM	TUBGCP5 →	+0.503	+2.751	.001	.002	3	2
UCEC	DHX37 →	+0.521	+2.753	<.001	.002	3	2
UCEC	FAM177A1 →	+0.366	+2.238	.005	.006	3	2
UCEC	ZNF117 →	-0.889	-3.796	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,981 associations by consensus.

RNA5SP413 by KERA expression — HNSC

Explore this box plot interactively →