KERA

Across TCGA pan-cancer cohorts, KERA RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KERA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KERA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KERA is over-expressed in tumor, although a few such as READ and PRAD show the opposite, repressed pattern.

KIRC, READ, and PRAD are the cancer types where KERA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KERA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.114	<.001	5	view →
READ	All	III,IV	−0.435	.018	3	view →
PRAD	All	All	−0.143	.018	2	view →
STAD	All	All	−0.472	.024	1	view →
CHOL	All	All	+0.053	.041	1	view →
KIRP	All	III,IV	+0.044	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KERA–KIRC

Open the KIRC breakdown →