KERA

Across TCGA patient cohorts, KERA mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KERA-associated genes across cancer lineages are PCNA, TIGAR, and ASNS. Each is linked with KERA in more than 1 cancer types. Because this analysis shows association rather than direction, both KERA-to-partner and partner-to-KERA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KERA-low versus KERA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KERA→partner) and Y-score (partner→KERA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.280	+2.415	.001	.003	3	2
UCEC	TIGAR →	+0.135	+1.933	.027	.009	3	2
UCEC	ASNS →	+0.446	+2.321	.002	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.952	+3.087	<.001	<.001	3	2
SKCM	AMPK_alpha →	+0.146	+3.000	.016	.035	3	1
SKCM	Smac →	+0.295	+2.820	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PCNA by KERA expression — UCEC

Explore this box plot interactively →