KERA

Across TCGA cell cohorts, KERA mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KERA-associated genes across cancer lineages are OR1N2, OR1D2, and IFNA2. Each is linked with KERA in more than 1 cancer types. Because this analysis shows association rather than direction, both KERA-to-partner and partner-to-KERA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N2 grouped by KERA-low versus KERA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KERA→partner) and Y-score (partner→KERA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1N2 →	+0.028	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR1D2 →	+0.020	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	IFNA2 →	+0.028	+5.189	<.001	<.001	3	1
BLOOD_Lymphoma	PF4 →	+0.044	+4.867	<.001	.009	3	1
SKIN	OR5B3 →	+0.038	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR1N2 by KERA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →