KDR

Across TCGA cell cohorts, KDR mutation is significantly associated with the mutation status of many other genes, with 7,027 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDR-associated genes across cancer lineages are ADAMTS12, CRACDL, and KCNG4. Each is linked with KDR in more than 5 cancer types. Because this analysis shows association rather than direction, both KDR-to-partner and partner-to-KDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS12 grouped by KDR-low versus KDR-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDR→partner) and Y-score (partner→KDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAMTS12 →	+3.357	+4.285	.005	.005	1	6
OVARY	CRACDL →	+5.415	+5.415	.004	.004	1	6
LARGE_INTESTINE	KCNG4 →	+4.693	+2.637	<.001	<.001	1	6
LARGE_INTESTINE	CDH9 →	+1.863	+1.863	.002	.002	1	6
LARGE_INTESTINE	MYH2 →	+2.208	+2.208	<.001	<.001	1	6
LUNG_NSCLC_LUAD	LYST →	+2.756	+2.756	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,027 associations by consensus.

ADAMTS12 by KDR expression — STOMACH

Explore this box plot interactively →